7/12/2023 0 Comments Human brain mapping abbreviation![]() Furthermore, a series of validation and robustness analyses demonstrated the reliability of the results. Moreover, FCS‐related genes were preferentially expressed in cortical neurons and young adulthood and were enriched in numerous neurodegenerative and neuropsychiatric disorders. ![]() The FCS‐related genes we identified were significantly enriched for ion channels, axon guidance, and synaptic transmission. We found that FCS spatial distribution was significantly positively correlated with the expression of genes defined by the first PLSR component. A multivariate technique of partial least squares regression (PLSR) was then conducted to identify genes whose spatial expression profiles best predicted the FCS distribution. Specifically, functional connectivity strength (FCS), also known as the “degree centrality” of weighted networks, is calculated to measure functional network centrality. In this study, functional networks were constructed, and the graph‐theory method was employed to calculate network centrality in 100 healthy young adults from the Human Connectome Project. However, at present, the molecular mechanisms associated with functional network centrality are still largely unknown. ![]() Resting‐state functional connectivity in the human brain is heritable, and previous studies have investigated the genetic basis underlying functional connectivity.
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